ACTIGRAFT - Product Presentation Brief
1. Background, Problem & Needs:
ACTIGRAFT is a revolutionary medical device for chronic wounds treatment.
Chronic wounds do not heal, or heal slowly, because an underlying defect impedes local blood
flow to the wound site and hinders the body’s natural wound healing processes. These types of
wounds may never heal, or take years to heal, causing patients severe emotional and physical
stress and creating a significant financial burden on patients and the whole healthcare system
and in addition could eventually lead to wound infection, necrosis and finally – amputation of
Patients suffering from chronic wounds, experience severe damage to their health, severe pain,
drowsiness (bad smell from the wound) and severe impairment of quality of life.
Several factors can contribute to chronic wounds, including:
- Diabetes mellitus
- Continued pressure
- Poor circulation
- Difficulty moving
- Systemic illnesses
- Repeated trauma
There are 3 main types of chronic wounds:
- Diabetic Ulcers
- Venous and Arterial Ulcers
- Pressure Ulcers
2. The Solution: Using ActiGraft® to Treat Chronic Wounds
Actigraft is the first wound care product that enables health care providers to produce – in real
time – in vitro blood clots from a patient’s whole blood. This innovative solution brings the
patient’s blood to the site of the chronic wound to initiate and support the body’s natural
Our general approach when treating with Actigraft, is to bypass the problem of low or nonexisting blood flow in the wound (the main cause of chronic wounds), by creating and applying
an external blood clot from the patient’s own blood, outside and over the wound.
Once applied, the blood clot tissue serves as a protective covering and supports wound healing
processes which naturally occur in the patient’s body.
The Challenge of Treating Chronic Wounds – including diabetic ulcers, venous and arterial ulcers,
and pressure ulcers, is that the wound often doesn’t heal or heal slowly because an underlying
defect is impeding blood flow to the wound site. This lack of blood prevents the body from
going through its natural wound healing processes.
ActiGraft’s technology is innovating the way we treat chronic wounds by managing each stage of
the wound healing process.
3. How ActiGraft® Works:
The blood clot recruits endothelial cells and fibroblasts to synthesize a permanent ECM.
The focus is filling and covering the wound.